Drugs that have a pronounced immunosuppressive effect are prescribed for the prevention of tissue rejection after surgery. Usually, such reactions of the body( tissue rejection) can occur during bone marrow transplantation. And among the analogues that have immunity-suppressing properties, it is worthwhile dwelling on the latest generation of Cyclosporine, which proved successful in the recovery period after the operation, and also with the high probability of irreversible reactions after surgical intervention.
Ciclosporin has a pronounced inhibitory effect on cellular responses, suspends the rate of flow of humoral processes in cells, while there is no adverse effect on phagocytic cells and their functioning. So, let's consider today the instructions for use and the price of Cyclosporine, reviews and analogues of such a drug.
Features of the preparation
To eliminate the negative reaction of the body to the interventions accompanying heart, liver, lung, kidney transplantation, the therapy is based on the joint administration of medications, whose action is aimed at preventing tissue rejection. A high level of exposure makes it possible in the shortest possible time to eliminate the possibility of possible negative reactions of the organism.
Because of the relatively small number of adverse events with this drug, Cyclosporine is prescribed as an alternative treatment in the case of using other types of immunosuppressants for "graft-versus-host disease": the absence of an allergic reaction makes it possible to assign it even to patients with hypersensitivity.
Composition of Cyclosporin
The composition balance determines the degree of effectiveness of the drug. The active substance in any dosage form of the drug is cyclosporin. In capsules, the amount of this substance depends on the volume of the capsules, it can contain 25, 50 and 100 mg in one capsule.
In the liquid solution of the drug intended for intravenous administration, the active substance is 50 or 650 ml.
Dosage Forms
Two dosage form preparations are available: capsules and a solution for intravenous administration. Capsules have an oblong shape, white color and a different volume, which assumes a different volume of active substance. Capsules are located in contour cells of 10 pieces each, the package contains 5 contour packs.
- The solution for intravenous administration is offered on sale in the form of ampoules of 5 or 1 ml.
- There is also an oil solution available on the market, which is used internally.
- Some pharmacies also offer eye drops of Cyclosporine, ointment and tablets.
The cost of the drug is considered quite affordable: depending on the type of dosage form, pharmacy and trade mark-up from 730 to 850 rubles per package.
Pharmacological action
The effect of the active substance begins practical immediately after its use. In this case, the absorption during the appointment of capsules occurs almost immediately after the administration of the drug. The absence of negative impact is determined by a balanced composition and a set of substances in the formulation.
Farmakodinamika
Due to its active action, the Cyclosporin drug extends the phase of preservation of transplants, preventing the occurrence of an allergic reaction in organ transplantation. By reducing the activity of immunity and protecting phagocytic cells, the active substance of the preparation does not allow to arise and activate inflammatory processes in tissues.
Pharmacokinetics
The process of cleavage of Cyclosporine occurs without the occurrence of side effects. The decay products are excreted by the liver and kidneys.
Indications
The most serious indications for the use of this drug should be considered the following conditions and diseases:
- for the prevention of allergic reactions and rejection of implants in the transplantation of organs such as the heart, kidney, liver, pancreas, heart, lungs;
- in the treatment of autoimmune diseases;
- as an immunosuppressive therapy for glomerulosclerosis;
- in the treatment of membranous glomerulonephritis, lupus nephritis, mesangioproliferative chronic glomerulonephritis;
- in the complex therapy of arthrosis and arthritis with the inability to use long-acting drugs;
- for many skin lesions:
- eczema of various nature,
- of psoriatic erythroderma;
- severe forms of psoriasis and its advanced stage;
- cold urticaria;
- often arising dermatitis( including bullous);
- with active uveitis;
- nephrotic syndrome - a complex effect allows to speed up the treatment of this condition.
Instruction for use
The use of Cyclosporine will depend on its dosage form.
- So, capsules are used for skin lesions 1-2 times a day, depending on the stage of the pathological process. Admission is carried out before meals, and the duration of admission depends on the general condition of the patient. The application can last from 1 week to a year and a half months with no side effects in treatment.
- With a marked decrease in the characteristic symptomatology, the dose of the drug used is reduced to 2-6 mg per day. Also, a decrease in the daily dose can be produced by joint treatment with other drugs with a similar effect.
- In the treatment of nephrotic syndrome, the agent is prescribed from a calculation of 1 mg per 1 kg of body weight. With a marked improvement in vision and removal of the inflammatory process, the dose gradually decreases, especially when complex treatment with other drugs with similar characteristics when exposed.
Contraindications
- Contraindications include serious damage to the liver, kidneys, as well as the last stage of heart failure.
- Children's age, as well as pregnancy should be considered contraindications when using the drug.
Side effects of
In case of hypersensitivity to constituents, the appearance of such side effects as:
- Skin rashes, accompanied by itching and mild burning of the skin.
- Tachycardia and malfunctions in the heart rhythm.
- Arrhythmia, a slight soreness in the heart.
- Lowering blood pressure.
With particularly severe negative manifestations, the occurrence of anaphylactic shock is likely, which requires the fastest medication to restore the patient's condition.
There may also be the occurrence of nausea, vomiting, deterioration of the digestive process. Diarrhea and other disorders of the intestine do not occur very often and can be caused by an increased sensitivity of the body to the active substance of the drug.
Special instructions
Special instructions include pregnancy, the period of breastfeeding and children's age. Due to the possibility of penetration of the active substance through the placenta into the body of the child, it is likely to have a negative effect, and penetration into breast milk should also cause the most attentive attitude towards the body of a woman and a newborn.
Interaction with other drugs
The use in a complex therapy of the drug is possible because of minimal interaction with other drugs. It should also be taken into account that with the combined use of Cyclosporine with non-steroids, anti-inflammatory drugs may cause side effects from the liver or kidneys, and with antibacterial agents, there is a high probability of organic changes in blood composition and kidney function.
Reviews of the drug Cyclosporin for psoriasis, atopic dermatitis and other ailments you will find below.
Reviews
- A modern drug, Cyclosporine has a lot of positive feedback from both patients who used it in complex treatment, and from doctors who prescribe this drug with the available indications.
- Rapid rendering of the necessary curative effect with the minimal amount of adverse events makes it possible to call the drug Ciclosporin one of the most effective drugs in the treatment and prevention of the probability of tissue rejection in the implantation of the heart, liver, kidneys and pancreas.
- Many also note the availability of cost: since the duration of treatment with this drug can be significant, the price is important when acquiring Cyclosporine.
- As an important characteristic of any medicinal product, many note the convenience of the drug: several dosage forms allow the best use of it in a particular case. The minimal number of possible side effects makes insignificant the probability of negative impact of the funds on the patient's body.
Analogues
The following drugs with similar therapeutic effect can be classified as analogous drugs:
- Cyclosporin HEXAL;
- Ecological;
- Cycloral-FS.
These drugs can also be prescribed for organ or bone marrow transplantation as a preventive and curative remedy with a wide spectrum of action.
about Cyclosporin will tell the video below: